UNIT 1. THE BRAIN
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THE BRAIN AND ITS FUNCTION
Did you know that your brain
is the size of a small cauliflower? weighs about 1.5 kilograms? is 80% water? consists of (probably) 100 billion neurons?
Did you know that it takes your brain about
1/10,000th of a second to respond to a stimulus? 90 seconds to decide whether you like someone or not? 20 minutes to realise that you feel full? 0.1 to 0.3 seconds to recognise familiar music?
The brain is the most complex and the least understood organ in the body. While we've learned a lot about it, much of what we assume "we have always known" wasn't actually discovered until quite recently. Take dopamine, an important neurotransmitter, for example. Until the 1950s, scientists thought it had little significance. And how about the hippocampus? Up until the 1950s, its exact function remained unknown. Similarly, no distinction had been made between different memory systems. When you think about it, you may realise that these remarkable discoveries were made in your grandparents' or even parents' day!
Neuroscience is a fast-developing field, but despite new discoveries, we still have a long way to go. We may learn how to effectively treat brain diseases, including mental and neurodegenerative disorders, when we ever get there.
The architecture of the human brain
Over the course of evolution, the human brain has tripled in size and developed three distinctive layers. The reptilian brain (brainstem, cerebellum and basal ganglia) evolved first. It has the most basic functions, such as breathing, heart rate, swallowing and balance. The limbic system (consisting of a set of brain structures associated with memory, emotions and arousal, such as the thalamus, hypothalamus, hippocampus, amygdala and olfactory bulbs) developed next. The neocortex was the last to develop. It is involved in higher brain functions, such as language, thought, attention, imagination and consciousness.
The brain is a delicate organ protected from injury by the skull, meninges and cerebrospinal fluid flowing from four ventricles. It comprises the cerebrum, the cerebellum and the brainstem. There are two main types of cells: glial cells and nerve cells, also called neurons, which form the nervous system. Glial cells are supporting cells that provide neurons with nutrients, protection and physical support. Neurons are considered the most important cells in the brain. They are each connected by synapses to thousands of other neurons, forming neural networks.
The cerebrum is the largest portion of the human brain. It consists of the cerebral cortex (also known as grey matter) and several subcortical structures, including the amygdala, the hippocampus, the thalamus, the hypothalamus and the olfactory bulbs.
Another group of subcortical structures is the basal ganglia. The basal ganglia (hidden underneath the cortex) are involved in controlling and executing movement, procedural learning and habit formation.
The cerebrum is divided into two hemispheres joined together by the corpus callosum. The right hemisphere controls the left side of the body, and the left hemisphere controls the right side. The hemispheres are in turn divided into four lobes: frontal, parietal, occipital and temporal.
Deep within the brain lie four large cavities called ventricles. They are filled with cerebrospinal fluid, which provides protection to the brain, nutrients and waste removal.
The cerebellum (the little brain) lies at the back of the brain and like the cerebrum has two hemispheres that are connected by the vermis. The cerebellum is essential for the regulation of posture and movement.
The brainstem, the part of the brain with the longest ancestry, is made of the midbrain, the pons and the medulla oblongata.
Exercise 1
Choose the correct answer.
Which of the following is the oldest region of the brain?
brainstem limbic system cerebrum cerebral cortex
Which of the following brain structures is not located in the limbic system?
hypothalamus pons amygdala hippocampus
Which of the following is a set of structures associated with movement?
basal ganglia brainstem cerebellum limbic system
Which of the following is a set of structures associated with procedural learning?
brainstem basal ganglia limbic system cerebellum
Which of the following parts of the brain enables communication between the left and right hemispheres?
cerebral aqueduct midbrain corpus callosum vermis
Which of the following is a set of structures associated with emotions and memory?
limbic system basal ganglia hippocampus brainstem
Which of the following is true for ventricles?
There is cerebrospinal fluid in them. They are located in large cavities. They cleanse the brain of toxins. They protect the brain from mechanical injury.
Which side of the body is affected if a person suffers a stroke in the brain's left hemisphere?
left right either
BRAIN HEMISPHERES AND LOBES
As it has already been mentioned, the brain is divided into two hemispheres joined by the corpus callosum: right and left. Although they look the same, each hemisphere specialises in different tasks. The specialisation of the hemispheres is called brain lateralisation. The best example of brain lateralisation is language, which is typically processed by the left hemisphere. Lateralisation, however, isn't the same in every person - in about one in ten people, language skills are in the right hemisphere and in another one in ten in both hemispheres. Lateralisation appears not to be fixed either. If a specific part of the brain is injured, its functions can be taken over by another part in the same or opposite hemisphere.
Each hemisphere is divided into four lobes: frontal, temporal, parietal and occipital.
The frontal lobe contains the motor cortex, which is essential for initiating movement; the prefrontal cortex involved in higher-level cognitive functioning; and Broca's area related to speech production.
The parietal lobe contains the somatosensory cortex, which processes and interprets sensory information from various body parts.
The temporal lobe includes the auditory cortex responsible for processing auditory information and Wernicke's area essential for language comprehension.
The occipital lobe contains the visual cortex, the area responsible for processing visual information.
Whilst each lobe is involved in different functions, they work together as a single unit.
The brain lobes and their main functions
Frontal
Temporal
Parietal
Occipital
movement
hearing, smell
integration of sensory information (e.g. touch, temperature, and pain)
vision
speech production
language comprehension
reading, writing, maths computation
interpretation of visual information
cognitive functions (e.g. thinking, planning, problem-solving, decision-making)
memory, learning, emotion
recognition of the size, shape and texture of objects
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regulation of emotions and social behaviour
object recognition
spatial orientation
-
Exercise 2
The picture below is a sagittal view of the human brain with some important parts numbered. Write their names in the spaces below.
__________ __________ __________ __________ __________ __________ __________ __________ __________ __________ __________ __________
Exercise 3
Decide if the following sentences are true (T) or false (F).
The two hemispheres function independently of each other. Each hemisphere specialises in different things. Language functions are typically lateralised to the right hemisphere. The frontal lobes specialise in vision. The temporal lobes allow you to feel the sun's warmth on your face. Thanks to the frontal lobes, you can refrain from pushing a person standing in your way. Without the parietal lobes, you wouldn't be able to make sense of what you are hearing.
Exercise 4
Match the following parts of the brain to their functions.
hippocampus, ventricles, cerebellum, basal ganglia, hypothalamus, thalamus, amygdala, cerebrum, pituitary gland, brainstem
__________ controls several basic body functions, such as respiration, digestion, heartbeat, blood pressure, sleep, swallowing, sneezing, vomiting and coughing. __________ controls voluntary movements such as posture, balance, and coordination, resulting in precise and balanced motor activity. __________ secretes hormones into the bloodstream and regulates other important endocrine glands. __________ are filled with cerebrospinal fluid (CBF), which helps to protect the brain from trauma, provide nutrients to the brain and remove waste products. __________ plays the role of converting information from short-term memory to long-term memory, and in spatial memory that enables navigation. __________ is responsible for the formation and storage of memories associated with emotional events. __________ regulates many complex functions of the organism, such as sleeping, eating, drinking, memorising, and body temperature; it stimulates or inhibits the secretion of hormones from the pituitary gland. __________ relays motor and sensory information (except smell) to the cerebral cortex; it regulates sleep, alertness and wakefulness. __________ regulates cognitive functions like speech, planning, reasoning, problem-solving, emotions and memory; it interprets sensory information like vision or hearing and controls voluntary movement. __________ plays an important role in non-declarative memory, such as procedural or habit learning, and involuntary motor movements.
Exercise 5
A group of people with brain injuries are gathered in the neurologist's waiting room. Before they are diagnosed, which area of their brain do you think could be damaged? Choose the correct option.
Paul has staggered into the waiting room, trying not to lose his balance.
thalamus medulla oblongata cerebellum amygdala
Kate's got lost on her way to the clinic, although she lives a short distance away.
pituitary gland hippocampus thalamus pons
Harry is eating his third hamburger because he is always hungry.
midbrain thalamus hippocampus hypothalamus
Steve, once a kind man, is very rude to everyone in the waiting room.
frontal lobe temporal lobe parietal lobe occipital lobe
Hannah is complaining of losing feeling in her left leg.
right sensory cortex right motor cortex left sensory cortex left motor cortex
Irene can't move her right arm and says she has difficulty in everyday activities, such as showering or dressing.
right sensory cortex right motor cortex left sensory cortex left motor cortex
Tanya has difficulty in getting the words out.
Broca's area Wernicke's area occipital lobe parietal lobe
Jack has breathing and swallowing difficulties and is lucky to be alive.
basal ganglia pituitary gland medulla oblongata amygdala
Beth's speech is fluent but makes no sense to others.
Broca's area Wernicke's area frontal lobe parietal lobe
11-year-old Mike stands a head taller than the next tallest person in the waiting room.
thalamus cerebellum medulla oblongata pituitary gland
Mr Stevens doesn't even remember who he is waiting for.
basal ganglia medulla oblongata hippocampus thalamus